Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity

Abstract excerpt

<title>Abstract</title> <p>While animal models have provided key insights into conserved mechanisms of how the lung forms during development, human-specific developmental mechanisms are not always captured. To fully appreciate how developmental defects and disease states alter the function of the lungs, studies in human lung models are important. Here, we sequenced >150,000 single single-cells from 19 healthy hum...

Topics

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• Congenital Diaphragmatic Hernia Studies
• Neonatal Respiratory Health Research
• Renal and related cancers
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

cb3da4d3-9c5b-521f-a866-e8eeb7e2437e

DOI

10.21203/rs.3.rs-3587319/v1