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High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors

2024-07-09

Abstract excerpt

The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a template for the production of custom DNA sequences by reverse transcription. The efficiency of reverse transcription is a major limiting step for retron technologies, but we lac...

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Literature Corpus work
7bca290f-938f-5215-90f3-8da2b2e64c9f
DOI
10.1101/2024.07.08.602561
Open publication

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High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene EditorsDOI 10.1101/2024.07.08.602561
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