Article

Pre-metabolic syndrome transcriptional response of adipose tissue and liver to obesity in the Ossabaw pig model

2025-12-06

Abstract excerpt

<title>Abstract</title> <p>Background The global rise in obesity prevalence highlights an urgent need to understand its underlying pathophysiology, which ranges from preclinical obesity (excess body fat without overt disease) to clinical obesity with impairment of organ function. To study obesity, we fed obesity-prone Ossabaw pigs a medium cholesterol (0.5 weight %), high-fat (50% of energy) and high-fructose (21...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4879adfc-7671-5655-ba2b-cb74ab60ff77
DOI: 10.21203/rs.3.rs-8039124/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pre-metabolic syndrome transcriptional response of adipose tissue and liver to obesity in the Ossabaw pig modelDOI 10.21203/rs.3.rs-8039124/v1Read

Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesitySemantic proximity Read

The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation.Semantic proximity Read

Meta-Inflammation and Endotoxemia in a Highly Translational Porcine Model of Diet-Induced ObesitySemantic proximity Read

Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs.Semantic proximity Read

Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location.Semantic proximity Read

Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swineSemantic proximity Read

Analysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition.Semantic proximity Read

The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.Semantic proximity Read

Differential metabolic and hepatic transcriptome responses of two miniature pig breeds to high dietary cholesterol.Semantic proximity Read

A transcriptome multi-tissue analysis identifies biological pathways and genes associated with variations in feed efficiency of growing pigs.Semantic proximity Read

Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine modelSemantic proximity Read

Transcriptional profiling of subcutaneous adipose tissue in Italian Large White pigs divergent for backfat thicknessSemantic proximity Read