Article

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node Metastasis

2025-08-22

Abstract excerpt

<h4>Objective</h4> This study aimed to define conserved molecular drivers of breast cancer lymph node metastasis (LNM) through an unbiased, multi-omics approach, resolving spatial and cellular mechanisms of stromal reprogramming. <h4>Methods</h4> We integrated three bulk RNA-seq datasets (GSE110590, GSE193103, GSE209998) to identify differentially expressed genes (DEGs) in LNMs versus primary tumors. Tissue-spec...

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Literature Corpus work: 7bb7cddf-a738-5ab6-b593-207fc019e61e
DOI: 10.1101/2025.08.18.670793

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