Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts.

Cancer letters - 28 Sept 2024

Zhang Qian, Ding Liang, Li Jingyi, Liu Kunyu, Xia Chengwan, Chen Sheng, Huang Xiaofeng, Pu Yumei, Song Yuxian, Hu Qingang, Wang Yuxin

Abstract excerpt

Desmoplasia in fibroblasts within metastatic lymph nodes (MLNs) serves as an indicator of extranodal extension (ENE), which led mortality in oral squamous cell carcinoma (OSCC). However, systematic studies on fibroblasts in MLNs are lacking. Therefore, this study characterized the differences in phenotype, function, and origin of fibroblasts between primary tumors (PTs) and lymph nodes (LNs) in OSCC. We generated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-Associated Fibroblasts
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Mouth Neoplasms

Share to Sequence Analysis, RNA

Share to Single-Cell Analysis

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Microenvironment

Source

Identifiers

PMID: 39154702
DOI: 10.1016/j.canlet.2024.217180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts.PMID 39154702Read ↗

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblastsSemantic proximity Read ↗

Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinomaSemantic proximity Read ↗

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node MetastasisSemantic proximity Read ↗

Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinomaSemantic proximity Read ↗

Proteogenomic Characterization of Primary Oral Squamous Cell Carcinomas Unveils the Extracellular Matrix Remodeling and Immunosuppressive Microenvironment Linked with Lymph Node MetastasisSemantic proximity Read ↗

Identification and mapping of human lymph node stromal cell subsets by combining single-cell RNA sequencing with spatial transcriptomicsSemantic proximity Read ↗

Single-cell RNA sequencing and traditional RNA sequencing reveals the role of Cancer-associated fibroblasts in Head and neck squamous cell carcinomas cohortSemantic proximity Read ↗

Integrated single-cell and bulk RNA sequencing reveals prognostic and immunotherapy-associated myofibroblastic cancer-associated fibroblast subtypes in head and neck squamous cell carcinomaSemantic proximity Read ↗

Classifying cancer-associated fibroblasts-The good, the bad, and the target.Semantic proximity Read ↗

Proteogenomic characterisation of primary oral cancer unveils extracellular matrix remodelling and immunosuppressive microenvironment linked to lymph node metastasisSemantic proximity Read ↗

Single-cell and Spatial Transcriptomic Mapping Reveals MSEC-myoCAF Interactions Driving Lymph Node Metastasis in Colorectal CancerSemantic proximity Read ↗

Single-cell analysis reveals the COL11A1+ fibroblasts are cancer-specific fibroblasts that promote tumor progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.