Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

21 Jan 2020

Abstract excerpt

Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopulations in metastatic lymph nodes (LN). Two myofibroblastic subsets, CAF-S1 and CAF-S4, accumulate in LN and correlate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Cancer Treatment Studies
Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31964880
DOI: 10.1038/s41467-019-14134-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanismsPMID 31964880Read ↗

Spatial and Single-Cell Dissection of Fibroblast Subpopulation Reprogramming Driving Stromal Collapse in Breast Cancer Lymph Node MetastasisSemantic proximity Read ↗

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencingSemantic proximity Read ↗

A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspectiveSemantic proximity Read ↗

scRNA-seq characterizing the heterogeneity of fibroblasts in breast cancer reveals a novel subtype SFRP4+ CAF that inhibits migration and predicts prognosisSemantic proximity Read ↗

Multi-omics analysis identifies BICC1+ fibroblasts drive triple negative breast cancer aggressiveness and poor prognosisSemantic proximity Read ↗

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironmentSemantic proximity Read ↗

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastasesSemantic proximity Read ↗

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic TargetsSemantic proximity Read ↗

Cancer-associated fibroblast compositions change with breast-cancer progression linking S100A4 and PDPN ratios with clinical outcomeSemantic proximity Read ↗

Cancer-associated fibroblast classification in single-cell and spatial proteomics data.Semantic proximity Read ↗

Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities.Semantic proximity Read ↗

A Cancer-Associated Fibroblast Classification Framework for Single-Cell DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.