Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

doi:10.1038/s41380-018-0258-3

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Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Molecular psychiatry - 1 Sept 2019

Audrain Mickael, Haure-Mirande Jean-Vianney, Wang Minghui, Kim Soong Ho, Fanutza Tomas, Chakrabarty Paramita, Fraser Paul, St George-Hyslop Peter H, Golde Todd E, Blitzer Robert D, Schadt Eric E, Zhang Bin, Ehrlich Michelle E, Gandy Sam

Abstract excerpt

TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain. Using transgenic or viral approaches, we characterized in mice the effects of TYROBP deficiency on the phenotypic and pathological evolution of...

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Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30283031
DOI: 10.1038/s41380-018-0258-3
PMCID: PMC6447470

Genes

TYROBP
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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