Article

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

2021-05-04

Abstract excerpt

<h4>Summary</h4> The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Development of host-directed therapeutics and prophylactics could limit such resistance and offer urgently needed protection against VOCs 3,4 . Attractive pharmacological ta...

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Literature Corpus work: 7b9f4a67-80bb-5bb3-9be2-cca83299678d
DOI: 10.1101/2021.05.03.442520

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