Article

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

2021-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-coronavirus-2 (SARS-CoV-2). Specifically, TMPRSS2 proteolytically processes the SARS-CoV-2 Spike (S) Protein, enabling virus-host membrane fusion and infection of the lungs. We present here an efficient recombinant production strategy for enzymatically active TMPRSS2 ec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 142744f1-461f-5e4a-8f8a-4f55e7819322
DOI: 10.1101/2021.06.23.449282

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activationDOI 10.1101/2021.06.23.449282Read

Structural Analysis of Experimental Drugs Binding to the COVID-19 Target TMPRSS2Semantic proximity Read

Structure of Human TMPRSS2 in Complex with SARS-CoV-2 Spike Glycoprotein and Implications for Potential TherapeuticsSemantic proximity Read

A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein ActivationSemantic proximity Read

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in miceSemantic proximity Read

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitorsSemantic proximity Read

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 TreatmentSemantic proximity Read

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.Semantic proximity Read

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19Semantic proximity Read

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistanceSemantic proximity Read

Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human CellsSemantic proximity Read

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 InfectivitySemantic proximity Read

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19Semantic proximity Read