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Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

19 Jan 2022

Abstract excerpt

Abstract Vaccine hesitancy and emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) escaping vaccine-induced immune responses highlight the urgency for new COVID-19 therapeutics. Engineered angiotensin-converting enzyme 2 (ACE2) proteins with augmented binding affinities for SARS-CoV-2 spike (S) protein may prove to be especially efficacious against multiple...

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PMID: 35046611
DOI: 10.1038/s41589-021-00965-6

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