Article

EPAS1 protects fibroblasts from replicative senescence through telomeric stability

2022-04-06

Abstract excerpt

Telomeres are nucleoprotein structures at the end of each chromosome and function to terminal protection and genomic stability maintenance. Telomeric damage and attrition is closely related to cell division disability and replicative senescence in vitro, as well as to physical aging in vivo. Exploration of valuable targets of enhancing telomeric stability and delaying the entry of senescence could benefit human he...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b95f8d7-4e93-5f6d-906a-b71a708719be
DOI: 10.21203/rs.3.rs-1488721/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

EPAS1 protects fibroblasts from replicative senescence through telomeric stabilityDOI 10.21203/rs.3.rs-1488721/v1Read

Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesisSemantic proximity Read

Telomere Shortening and Its Association with Cell Dysfunction in Lung DiseasesSemantic proximity Read

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcriptionSemantic proximity Read

Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axisSemantic proximity Read

PES1 is a critical component of telomerase assembly and regulates cellular senescenceSemantic proximity Read

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere UncappingSemantic proximity Read

Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level InferencesSemantic proximity Read

Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere ShorteningSemantic proximity Read

LEF1 isoforms regulate cellular senescence and agingSemantic proximity Read

Respiratory muscle senescence in ageing and chronic lung diseasesSemantic proximity Read

Telomere maintenance pathway activity analysis enables tissue- and gene-level inferencesSemantic proximity Read

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasisSemantic proximity Read