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Article

PES1 is a critical component of telomerase assembly and regulates cellular senescence

3 May 2019

Abstract excerpt

Telomerase defers the onset of telomere shortening and cellular senescence by adding telomeric repeat DNA to chromosome ends, and its activation contributes to carcinogenesis. Telomerase minimally consists of the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR). However, how telomerase assembles is largely unknown. Here, we demonstrate that PES1 (Pescadillo), a protein overexpressed in many...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 31106266
DOI: 10.1126/sciadv.aav1090

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