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Article

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription

1 Jul 2016

Abstract excerpt

DNA breaks activate the DNA damage response and, if left unrepaired, trigger cellular senescence. Telomeres are specialized nucleoprotein structures that protect chromosome ends from persistent DNA damage response activation. Whether protection can be enhanced to counteract the age-dependent decline in telomere integrity is a challenging question. Telomeric repeat-containing RNA (TERRA), which is transcribed from...

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Identifiers

PMID: 27819056
DOI: 10.1126/sciadv.1600031

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