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Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences

7 Apr 2021

Abstract excerpt

Telomere maintenance is one of the mechanisms ensuring indefinite divisions of cancer and stem cells. Good understanding of telomere maintenance mechanisms (TMM) is important for studying cancers and designing therapies. However, molecular factors triggering selective activation of either the telomerase dependent (TEL) or the alternative lengthening of telomeres (ALT) pathway are poorly understood. In addition,...

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PMID: 33897770
DOI: 10.3389/fgene.2021.662464

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