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Article

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

22 Feb 2019

Abstract excerpt

RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also...

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PMID: 30796637
DOI: 10.1007/s13238-019-0610-7

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