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Article

Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis

1 Dec 2017

Abstract excerpt

BACKGROUND: Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying the effects of advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) represents a type of long noncoding RNA. In this study, the regulatory roles of TERRA on human telomeres and mitochondria and IPF epithelial injury model were identified. METHODS: Blood samples...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 29197377
DOI: 10.1186/s12890-017-0516-1

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