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Article

Clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance: 2023 update on clinical associations and management recommendations.

American journal of hematology - 1 Jun 2023

Mangaonkar Abhishek A, Patnaik Mrinal M

Abstract excerpt

CONDITION OVERVIEW: Clonal hematopoiesis (CH) refers to age-associated expansion of somatic variants in hematopoietic stem and progenitor cells (HSPC). DIAGNOSIS: CH of indeterminate potential (CHIP) is operationally defined as pathogenic variants in HSPCs at a variant allele frequency ≥2%. CLINICAL ASSOCIATIONS: CH is associated with increased occurrence of several hematological conditions such as cytopenias...

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PMID: 36938794
DOI: 10.1002/ajh.26915

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