Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease.

Molecular genetics & genomic medicine - 1 Dec 2021

Bennett Craig L, La Spada Albert R

Abstract excerpt

BACKGROUND: Senataxin (SETX) is a DNA/RNA helicase critical for neuron survival. SETX mutations underlie two inherited neurodegenerative diseases: Ataxia with Oculomotor Apraxia type 2 (AOA2) and Amyotrophic Lateral Sclerosis type 4 (ALS4). METHODS: This review examines SETX key cellular processes and we hypothesize that SETX requires SUMO posttranslational modification to function properly. RESULTS: SETX is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exosomes
Share to Motor Neuron Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multifunctional Enzymes

Share to RNA Helicases

Share to RNA Polymerase II

Share to RNA Stability

Share to S Phase

Share to Sumoylation

Source

Open in PubMed Open full text

Identifiers

PMID: 34263556
DOI: 10.1002/mgg3.1745
PMCID: PMC8683630

Genes

SETX
H2AX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease.PMID 34263556Read ↗

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.Semantic proximity Read ↗

Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration.Semantic proximity Read ↗

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulationSemantic proximity Read ↗

Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.Semantic proximity Read ↗

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factorSemantic proximity Read ↗

Unwinding the role of senataxin in neurodegeneration.Semantic proximity Read ↗

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALSSemantic proximity Read ↗

Integrated Genome and Transcriptome Analyses Reveal the Mechanism of Genome Instability in Ataxia with Oculomotor Apraxia 2Semantic proximity Read ↗

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loopsSemantic proximity Read ↗

Role of Senataxin in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2.Semantic proximity Read ↗

High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.