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Article

Urinary cell transcriptomics and acute rejection in human kidney allografts

26 Feb 2020

Abstract excerpt

BACKGROUNDRNA sequencing (RNA-Seq) is a molecular tool to analyze global transcriptional changes, deduce pathogenic mechanisms, and discover biomarkers. We performed RNA-Seq to investigate gene expression and biological pathways in urinary cells and kidney allograft biopsies during an acute rejection episode and to determine whether urinary cell gene expression patterns are enriched for biopsy transcriptional...

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PMID: 32102984
DOI: 10.1172/jci.insight.131552

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