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Article

Association of LAG3 genetic variation with an increased risk of PD in Chinese female population.

Journal of neuroinflammation - 17 Dec 2019

Guo Wenyuan, Zhou Miaomiao, Qiu Jiewen, Lin Yuwan, Chen Xiang, Huang Shuxuan, Mo Mingshu, Liu Hanqun, Peng Guoyou, Zhu Xiaoqin, Xu Pingyi

Abstract excerpt

BACKGROUND: Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson's disease (PD) and the toxic fibrillary α-syn binds lymphocyte-activation gene 3 (LAG3) receptor that mediates α-syn transmission. The deletion of LAG3 in animal models was shown to limit α-syn spreading and alleviate the pathological changes of dopaminergic neurons...

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Identifiers

PMID: 31847878
DOI: 10.1186/s12974-019-1654-6
PMCID: PMC6918662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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