Article

YAP signaling promotes resistance to MEK and AKT inhibition in <i>NF1</i> -related MPNSTs

2025-06-20

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a tumor predisposition syndrome caused by loss of function of the neurofibromin protein. Malignant peripheral nerve sheath tumors (MPNSTs) are a rare and deadly sarcoma with few therapeutic options that are the leading cause of death for patients with NF1. To date, no targeted therapies have been approved for MPNST treatment, highlighting the need for an understanding of adaptive...

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Literature Corpus work: 5596135f-4508-525d-8075-7d1674ef953f
DOI: 10.1101/2025.06.16.659334

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