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Chromosome 8 gain is associated with high-grade transformation in MPNST

28 Feb 2021

Abstract excerpt

One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is the malignant peripheral nerve sheath tumor (MPNST), an aggressive and often fatal sarcoma that commonly arises from benign plexiform neurofibromas. Despite advances in our understanding of MPNST pathobiology, there are few effective therapeutic options, and no investigational agents have proven successful in clinical...

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PMID: 33591953
DOI: 10.1172/jci.insight.146351

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Chromosome 8 gain is associated with high-grade transformation in MPNSTPMID 33591953Read ↗

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A Sequencing Overview of Malignant Peripheral Nerve Sheath Tumors: Findings and Implications for TreatmentSemantic proximity Read ↗

New models for MPNST: establishment and comprehensive characterization of two tumor cell linesSemantic proximity Read ↗

<i>Ex vivo</i> to <i>in vivo</i> model of malignant peripheral nerve sheath tumors for precision oncologySemantic proximity Read ↗

Multi-omics integration of malignant peripheral nerve sheath tumors nominates therapies based on chromosome 8q statusSemantic proximity Read ↗

Establishment and characterization of a recurrent MPNST primary cell line:RsNFSemantic proximity Read ↗

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