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Article

PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors

2026-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas with poor prognosis and a strong tendency for metastasis and relapse. Surgical removal remains the mainstay of treatment but is frequently ineffective or impractical. Currently, no effective targeted therapy exists for this type of malignancy. PRMT5 has recently emerged as a promising therapeutic target in various h...

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Literature Corpus work
1d4639ae-2425-5e6f-bf58-b4578caaaf28
DOI
10.64898/2026.03.09.710638
Open publication

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