Article

Bitter taste receptor-stimulated nitric oxide innate immune responses are reduced by loss of CFTR function in nasal epithelial cells and macrophages

2022-09-22

Abstract excerpt

Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the tongue but expressed all over the body, including in airway cilia and macrophages, where T2Rs serve an immune role. T2R isoforms detect bitter metabolites (quinolones and acyl-homoserine lactones) secreted by gram negative bacteria, including Pseudomonas aeruginosa , a major pathogen in cystic fibrosis (CF). T2R activation by bitter b...

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Literature Corpus work: 7b593ed1-29ef-5cce-b819-abc6086bb431
DOI: 10.1101/2022.09.21.508717

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