Article

A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity

2020-01-01

Abstract excerpt

Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the contractile differentiation markers and show increased migration, proliferation and secretion of proinflammatory cytokin...

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Literature Corpus work: e96c74ec-0c13-548c-873f-3cd013083891
DOI: 10.17863/cam.49066

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