Article

Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease

2020-01-01

Abstract excerpt

Deregulation of vascular smooth muscle cell (VSMC) phenotypic switching is implicated in vascular disease development and VSMCs produce the majority of cells in late-stage atherosclerotic plaques. However, VSMC accumulation in mouse models of vascular disease arises from clonal expansion of very few medial cells. The source of these cells and mechanism of their selection are unknown. Hypothesising that VSMCs which...

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Literature Corpus work: 37b39315-f40c-5767-a1c5-4e05bfe80c41
DOI: 10.17863/cam.55876

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