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Article

Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection

19 Jan 2012

Abstract excerpt

Accumulation of mis- and unfolded proteins during viral replication can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR). If unchecked, this process may induce cellular changes detrimental to viral replication. In the report, we investigated the impact of HSV-1 on the UPR during lytic replication. We found that HSV-1 effectively disarms the UPR in early stages of...

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PMID: 22270612
DOI: 10.1007/s12192-012-0324-8

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