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HIV infection and antiretroviral therapy lead to unfolded protein response activation

14 May 2015

Abstract excerpt

BACKGROUND: The unfolded protein response (UPR) is one of the pathways triggered to ensure quality control of the proteins assembled in the endoplasmic reticulum (ER) when cell homeostasis is compromised. This mechanism is primarily composed of three transmembrane proteins serving as stress sensors: PKR-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 (IRE1). These...

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PMID: 25976933
DOI: 10.1186/s12985-015-0298-0

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