Article

Wilms Tumorigenesis in Human Kidney Organoids

2021-02-02

Abstract excerpt

<h4>SUMMARY</h4> The loss or failure of cell differentiation is a hallmark of cancer, yet whether perturbation of differentiation is causal or consequential to malignant transformation is largely unclear. Wilms tumor is the most widespread kidney cancer in children. Here, we establish a model for Wilms tumorigenesis in human kidney organoids. We show that loss of the tumor suppressor WT1 during organoid formatio...

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Literature Corpus work: 7b381327-5deb-5295-9299-887c21d14925
DOI: 10.1101/2021.02.02.429313

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