Article
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Human molecular genetics - 1 May 2010
Royer-Pokora Brigitte, Busch Maike, Beier Manfred, Duhme Constanze, de Torres Carmen, Mora Jaume, Brandt Artur, Royer Hans-Dieter
Abstract excerpt
Wilms tumors (WTs) are genetically heterogeneous kidney tumors whose cells of origin are unknown. Tumors with WT1 mutations and concomitant loss of the wild-type allele represent a distinct subgroup, frequently associated with mutations in CTNNB1. Here, we describe the establishment and characterization of long-term cell cultures derived from five individual WTs with WT1 mutations. Three of these tumor cell lines...
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