Article

iPSC-derived Cancer Organoids Recapitulate Genomic and Phenotypic Alterations of c- <i>met</i> -mutated Hereditary Kidney Cancer

2019-01-11

Abstract excerpt

<h4>SUMMARY</h4> Hereditary cancers with cancer-predisposing mutations represent unique models of human oncogenesis as a driving oncogenic event is present in germline, exposing the healthy member of a family to the occurrence of cancer. The study of the secondary events in a tissue-specific manner is now possible by the induced pluripotent stem cell (iPSC) technology offering the possibility to generate an unlim...

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Literature Corpus work: 843c12be-eff2-5591-bc79-756393ad21b5
DOI: 10.1101/518456

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