Article
Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice.
Disease models & mechanisms - 1 Aug 2015
Berry Rachel L, Ozdemir Derya D, Aronow Bruce, Lindström Nils O, Dudnakova Tatiana, Thornburn Anna, Perry Paul, Baldock Richard, Armit Chris, Joshi Anagha, Jeanpierre Cécile, Shan Jingdong, Vainio Seppo, Baily James, Brownstein David, Davies Jamie, Hastie Nicholas D, Hohenstein Peter
Abstract excerpt
Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the...
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