Article

Genotype-phenotype correlations and de novo induction of cancer stem cells in Wilms tumor initiation

2025-11-19

Abstract excerpt

<h4>Summary</h4> Wilms tumor, the most common pediatric kidney cancer, arises from abnormal embryonic kidney development. Therapy resistance and tumor recurrence remain major challenges, likely driven by the presence of Cancer Stem Cells (CSCs). Here, we elucidate the earliest pathogenic events in genetically engineered mouse models exhibiting loss of Wt1 or LIN28B overexpression, two Wilms tumor driver genes....

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Literature Corpus work: 3bd58a34-7615-539c-88dd-0806365144b2
DOI: 10.1101/2025.11.19.689177

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