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YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells

3 Feb 2022

Abstract excerpt

To date, identification of nonislet-specific transcriptional factors in the regulation of insulin gene expression has been little studied. Here, we report that the expression level of the transcription factor YY1 is increased dramatically in both human and mouse pancreatic β-cells after birth. Nevertheless, the physiological role of YY1 during β-cell development and its regulatory mechanism in β-cell function...

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PMID: 35113157
DOI: 10.2337/db21-0695

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