Article

Lower left ventricular ejection time in<i>MYBPC3</i>variant carriers with overt or subclinical hypertrophic cardiomyopathy

2024-10-16

Abstract excerpt

<h4>Aims</h4> Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy mainly caused by pathogenic variants in MYBPC3 and MYH7, encoding myosin binding protein C3 and myosin heavy chain 7, respectively. These variants can cause increased actin-myosin crossbridge cycling resulting in ventricular hypercontractility. Little is known about genotype-specific differences. Mice lacking Mybpc3 exhibited reduced le...

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Literature Corpus work: 7b23df55-7858-571a-94a4-66908b5361f3
DOI: 10.1101/2024.10.15.24315469

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