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Article

The Long-Term Clinical Progression of Genotype-Positive/Phenotype-Negative Patients With Hypertrophic Cardiomyopathy.

The American journal of cardiology - 15 May 2026

Puchnerova Veronika, Jensovsky Michael, Zoubkova Veronika, Peldova Petra, Votypka Pavel, Macek Milan, Ostadal Petr, Bonaventura Jiri

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease. In 20% to 30% of patients, a disease-causing variant can be identified and may also be present in relatives. Individuals carrying a pathogenic variant (G+) without left ventricular hypertrophy (LVH) are classified as genotype-positive/phenotype-negative (G+/P-). Their risk of developing LVH or HCM-related events remains uncertain. The aim of the...

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Source

Identifiers

PMID: 41759561
DOI: 10.1016/j.amjcard.2026.02.042

Genes

MYBPC3
MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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