Article

Gene positive vs. gene negative clinical and structural outcomes in hypertrophic cardiomyopathy patients: a meta-analysis and systematic review

2025-12-17

Abstract excerpt

<h4>Background</h4> Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease associated with increased risks of heart failure, sudden cardiac death (SCD), and stroke. Over 1,400 pathogenic variants, primarily in MYH7 and MYBPC3, have been identified, yet the prognostic significance of genetics remains unclear. Recent studies suggest genotype-positive (G+) HCM is linked to earlier diagnosis,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6f1d2e6-156a-5bf2-b1f1-7340b0b652b3
DOI: 10.64898/2025.12.16.25342182

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene positive vs. gene negative clinical and structural outcomes in hypertrophic cardiomyopathy patients: a meta-analysis and systematic reviewDOI 10.64898/2025.12.16.25342182Read

Genotype-Phenotype Correlations Identify Phenotypic Differences in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy in the NHLBI HCM RegistrySemantic proximity Read

Genetic determinants of the phenotype in a Swedish cohort of patients with hypertrophic cardiomyopathySemantic proximity Read

Genetics of hypertrophic cardiomyopathy: A review of current state.Semantic proximity Read

The Long-Term Clinical Progression of Genotype-Positive/Phenotype-Negative Patients With Hypertrophic Cardiomyopathy.Semantic proximity Read

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.Semantic proximity Read

Role of Genetics in Diagnosis and Management of Hypertrophic Cardiomyopathy: A Glimpse into the FutureSemantic proximity Read

Genotype Predicts Heart Failure Independent of LVEF, Peak VO2, and NT-proBNP Levels in Hypertrophic Cardiomyopathy.Semantic proximity Read

Comparing echocardiographic characteristics in genotype positive-phenotype positive hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy.Semantic proximity Read

Genotype‐Positive Status Is Associated With Poor Prognoses in Patients With Left Ventricular Noncompaction CardiomyopathySemantic proximity Read

Genotype-phenotype associations in sarcomeric hypertrophic cardiomyopathy associated with mutations in the MYBPC3 gene: Systematic review and meta-analysis.Semantic proximity Read

Genetic Determinants of Clinical Phenotype in Hypertrophic CardiomyopathySemantic proximity Read

Gene-echocardiography: refining genotype-phenotype correlations in hypertrophic cardiomyopathy.Semantic proximity Read