Article
Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure.
European journal of heart failure - 1 Nov 2011
Waldmüller Stephan, Erdmann Jeanette, Binner Priska, Gelbrich Götz, Pankuweit Sabine, Geier Christian, Timmermann Bernd, Haremza Janine, Perrot Andreas, Scheer Steffen, Wachter Rolf, Schulze-Waltrup Norbert, Dermintzoglou Anastassia, Schönberger Jost, Zeh Wolfgang, Jurmann Beate, Brodherr Turgut, Börgel Jan, Farr Martin, Milting Hendrik, Blankenfeldt Wulf, Reinhardt Richard, Özcelik Cemil, Osterziel Karl-Josef, Loeffler Markus, Maisch Bernhard, Regitz-Zagrosek Vera, Schunkert Heribert, Scheffold Thomas
Abstract excerpt
AIMS: Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) can both be due to mutations in the genes encoding β-myosin heavy chain (MYH7) or cardiac myosin-binding protein C (MYBPC3). The aim of the present study was to determine the prevalence and spectrum of mutations in both genes in German HCM and DCM patients and to establish novel genotype-to-phenotype correlations. METHODS AND RESULTS: Coding...
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