Article

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

2024-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Myosin inhibitor mavacamten is the only targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3 ). Here, we have examined whether the reported limited efficacy of mavacamten in a fraction of HCM patients can res...

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Literature Corpus work: ef975fdf-5902-5adc-9b5e-d90944653fc8
DOI: 10.1101/2024.03.22.584986

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