Article

<i>MYBPC3</i> D389V Variant Induces Hypercontractility in Cardiac Organoids

2024-05-30

Abstract excerpt

<h4>BACKGROUND</h4> MYBPC3 , encoding cardiac myosin binding protein-C (cMyBP-C), is the most mutated gene known to cause hypertrophic cardiomyopathy (HCM). However, since little is known about the underlying etiology, additional in vitro studies are crucial to defining the underlying molecular mechanisms. Accordingly, this study aimed to investigate the molecular mechanisms underlying the pathogenesis of HCM as...

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Literature Corpus work: a5324e2f-ee63-5916-ac02-4f5cda1d8a8d
DOI: 10.1101/2024.05.29.596463

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