Article

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology

2025-02-06

Abstract excerpt

<h4>Background</h4> The Hierarchical Taxonomy of Psychopathology (HiTOP) and Research Domain Criteria (RDoC) frameworks emphasize transdiagnostic and mechanistic aspects of psychopathology, respectively. We used a multi-omics approach to examine how externalizing (EXT), internalizing (INT), and shared EXT+INT liability map onto these models. <h4>Methods</h4> We conducted analyses across five RDoC units of analysis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85d25d63-7e7a-5f5f-bcc2-1fc953c33ca3
DOI: 10.1101/2025.02.05.25321732

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing PsychopathologyDOI 10.1101/2025.02.05.25321732Read

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing PsychopathologySemantic proximity Read

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology SpectraSemantic proximity Read

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Semantic proximity Read

Shared Genetic Liability across Systems of Psychiatric and Physical Illness.Semantic proximity Read

Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.Semantic proximity Read

Testing structural models of psychopathology at the genomic levelSemantic proximity Read

Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program CohortSemantic proximity Read

The boundaries of the internalizing and externalizing genetic spectra in men and women.Semantic proximity Read

Genetic Liability for Internalizing–Externalizing Traits in Mexican Youth: Moderation by AdversitySemantic proximity Read

Redefining Phenotypes to Advance Psychiatric Genetics: Implications from Hierarchical Taxonomy of PsychopathologySemantic proximity Read

Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.Semantic proximity Read

Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.Semantic proximity Read