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Article

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex.

Nature genetics - 1 Mar 2025

Schwaba Ted, Mallard Travis T, Maihofer Adam X, Rhemtulla Mijke, Lee Phil H, Smoller Jordan W, Davis Lea K, Nivard Michel G, Grotzinger Andrew D, Tucker-Drob Elliot M

Abstract excerpt

Differences in the patterning of genetic sharing between groups of individuals may arise from biological pathways, social mechanisms, phenotyping and ascertainment. We expand genomic structural equation modeling to allow for testing genomic structural invariance (GSI), that is, the formal comparison of multivariate genetic architecture across groups. We apply GSI to compare the autosomal multivariate genetic...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40055480
DOI: 10.1038/s41588-025-02093-6
PMCID: PMC12022846

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