Article

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8 <sup>+</sup> T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

2026-07-31

Abstract excerpt

<h4>Purpose</h4> Liver metastases confer poor outcomes and attenuate the benefit of immunotherapy across solid tumors. This study investigated how the hepatic metastatic niche promotes CD8⁺ T cell dysfunction and immunotherapy resistance in small-cell lung cancer (SCLC). <h4>Experimental Design</h4> Clinical outcomes and tumor gene expression were integrated with multi-region single-cell RNA sequencing of T cell...

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Literature Corpus work: 7b158cfa-3cac-553c-9fda-c41099cfc8c8
DOI: 10.64898/2026.07.30.741857

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Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8 <sup>+</sup> T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastasesDOI 10.64898/2026.07.30.741857Read

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