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Article

Distinct Spatial Programs of Response versus Resistance in Non-Small Cell Lung Cancer after Neoadjuvant Chemoimmunotherapy

2026-04-07

Abstract excerpt

<h4>Background</h4> Neoadjuvant chemoimmunotherapy (nCIT) has become a standard treatment for locally advanced resectable non-small cell lung cancer (NSCLC), yet the spatial biology underlying treatment resistance remains poorly understood. We used spatial transcriptomics to define the microenvironmental architecture of residual cancers in patients who did not achieve major pathologic response (non-MPR) compared...

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Literature Corpus work
5a90df5f-6122-5188-bed9-bb16f6a60601
DOI
10.64898/2026.04.05.716543
Open publication

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Distinct Spatial Programs of Response versus Resistance in Non-Small Cell Lung Cancer after Neoadjuvant ChemoimmunotherapyDOI 10.64898/2026.04.05.716543
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