Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance

Abstract excerpt

<h4>ABSTRACT</h4> Brain metastasis (BM) in renal cell carcinoma (RCC) remains poorly understood and often resistant to immune checkpoint inhibitors. We generated a large single-nucleus RNA-seq data of RCC BM, profiling 14 BM samples alongside matched extracranial metastases and primary tumors. Tumor cells in BM displayed neuronal infiltration, neural-like adaptation, and marked remodeling of the microenvironment,...

Topics

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• Immune Evasion
• Lymphocyte Activation
• Lymphocytes, Tumor-Infiltrating
• Mice, Nude
• Myeloid Cells
• Principal Component Analysis
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

3ecb2fe4-2905-5731-a23d-142c2ebd1d37

DOI

10.64898/2026.05.06.722652