Article

Development of a Norway Rat Hepacivirus Reporter for High-Throughput Quantification of Neutralising Antibodies

2025-11-13

Abstract excerpt

Hepatitis C virus (HCV) remains a major global health challenge, with vaccine research hindered by lack of immunocompetent animal models. Infection with the HCV-related Norway rat hepacivirus 1 (NrHV) in rats or mice shares HCV defining characteristics, including chronicity, delayed immune responses, and liver disease, thereby providing immunocompetent small animal models for immune responses and pathology. Infect...

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Literature Corpus work: 7ae47834-5bc1-5c40-9b7f-074695fadba8
DOI: 10.1101/2025.11.13.688247

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