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Article

Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice.

Gut - 1 Mar 2023

Alzua Garazi Pena, Pihl Anne Finne, Offersgaard Anna, Duarte Hernandez Carlos Rene, Duan Zhe, Feng Shan, Fahnøe Ulrik, Sølund Christina, Weis Nina, Law Mansun, Prentoe Jannick C, Christensen Jan Pravsgaard, Bukh Jens, Gottwein Judith Margarete

Abstract excerpt

OBJECTIVE: A prophylactic vaccine is needed to control the HCV epidemic, with genotypes 1-3 causing >80% of worldwide infections. Vaccine development is hampered by HCV heterogeneity, viral escape including protection of conserved neutralising epitopes and suboptimal efficacy of HCV cell culture systems. We developed cell culture-based inactivated genotype 1-3 HCV vaccine candidates to present natively folded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35918103
DOI: 10.1136/gutjnl-2021-326323
PMCID: PMC9933178

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