Article
JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization.
Hepatology (Baltimore, Md.) - 1 Nov 2024
Collignon Laura, Holmbeck Kenn, Just Ashley, Verhoye Lieven, Velázquez-Moctezuma Rodrigo, Fahnøe Ulrik, Carlsen Thomas H R, Law Mansun, Prentoe Jannick, Scheel Troels K H, Gottwein Judith M, Meuleman Philip, Bukh Jens
Abstract excerpt
BACKGROUND AND AIMS: HCV infection continues to be a major global health burden despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV-permissive animal models tractable in vaccination and challenge studies. Currently, only antibody neutralization studies in infectious cell culture systems or studies of protection by passive immunization of...
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