Article

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

2023-03-19

Abstract excerpt

<h4>Background & Aims</h4> Human genetic variation is thought to guide the outcome of hepatitis C virus (HCV) infection but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus (NrHV), closely related to HCV, causes chronic liver infection in rats but causes acute self-limiting hepatitis in typical strains of laboratory mice, which resolves in two weeks. The Coll...

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Literature Corpus work: 05a5c2f1-062f-5e1a-a9af-913aa5629450
DOI: 10.1101/2023.03.18.533278

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