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Generation of a HiBiT-expressing recombinant rat hepacivirus supporting both <i>in vivo</i> and <i>in vitro</i> infection

2025-11-26

Abstract excerpt

The lack of immuno-competent animal models of hepatitis C virus (HCV) infection has been an obstacle to vaccine development and research on immune responses. Hepacivirus ratti (Norway rat hepacivirus-1: NRHV1) is a virus closely related to HCV that specifically infects the liver and induces hepatocellular carcinoma in rats, making it a promising surrogate model for HCV. NRHV1 expressing a reporter gene serves as...

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Literature Corpus work
69a94974-c16a-5eb9-a075-018892b11d27
DOI
10.1101/2025.11.25.690605
Open publication

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Generation of a HiBiT-expressing recombinant rat hepacivirus supporting both <i>in vivo</i> and <i>in vitro</i> infectionDOI 10.1101/2025.11.25.690605
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